House treats a famous soap opera star when he believes the patient has a serious condition even though there's no evidence indicating that's the case. Meanwhile, Wilson and Amber have their first fight.
House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy's orders to give performance reviews, and fighting with Amber over who gets to spend more time with Wilson.
House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.